Remember that only one of these phrases uses 'of':Despite the heavy weather, the barbecue went ahead.
In spite of the heavy weather, the barbecue went ahead.
'Despite' is much more commonly used, especially at the start of a sentence.
Also possible here is 'regardless of' and (for those formal occasions) 'notwithstanding' .
Remember that both 'despite' and 'in spite of' can also be used with a gerund (-ing):
Despite reading the whole night, I did not finish the book.
In spite of reading the whole night, I did not finish the book.
Once again, 'despite' is more commonly used.
Do not use a subject pronoun - I, you, he, she - and a verb straight after these words. Instead, switch to 'even though':
Even though I read the whole night, I did not finish the book.
Even though the weather was heavy, the barbecue went ahead.
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